CSF - 1 receptor - regulated macrophage proliferation 1 Macrophage Proliferation is Regulated Through CSF - 1 Receptor
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چکیده
Background: Activation loop Y807F or juxtamembrane domain Y559F mutations compromise CSF-1 receptor-mediated macrophage proliferation. Results: Tyr-559 suppresses constitutive proliferative activity of Tyr-807; ligand-induced Tyr559 phosphorylation relieves this inhibition and activates pathways. Conclusion: Tyr-807 drives proliferation. Tyr-559 confers ligand dependence. Significance: How individual CSF-1 receptor tyrosines regulate receptor activation and signaling is critical for understanding the function of this disease-relevant receptor.
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تاریخ انتشار 2012